Scientists: Cutting the NIH budget could dismantle our ability to address real problems
OREANDA-NEWS. More than 90 percent of new drugs received funding from the National Institutes of Health. Now, US President Donald Trump’s proposed budget calls for cutting the NIH budget by 21 percent, or about $7.2 billion.
“Cutting the NIH budget could dismantle our ability to address real problems,” says Michael S. Kinch, a professor of biochemistry and molecular biophysics at Washington University in St. Louis.
“Take antibiotics, for example. We’ve grown accustomed to being able to treat infections, but now bacteria are becoming resistant to existing drugs. If funding cuts slow the development of new infection-fighting medicines, then in future years, many people may die from infections that once were treatable.”
Researchers analyzed budget data from the NIH and the Food and Drug Administration (FDA) to learn how much NIH support contributed to the early development of commonly prescribed drugs. They also zeroed in on newer drugs that were approved by the FDA in the past decade.
An analysis of the 100 most commonly prescribed drugs in the US—such as Synthroid, which replaces the hormone normally secreted by the thyroid gland; Crestor, a statin used to lower cholesterol; and albuterol, an inhaled treatment for people with lung diseases such as asthma—show that 93 percent had received NIH funding. For drugs approved by the FDA from 2010 to 2016, the percentage that relied on NIH support was even higher: 97 percent.
The findings appear as a letter in Cell Chemical Biology.
“NIH funding is instrumental in the early research needed to develop FDA-approved medicines,” says Kinch, director of the Center for Research Innovation in Biotechnology and Center for Drug Discovery. “Our data suggest that the development of newer drugs is becoming even more dependent on NIH funding.”
Further, because it can take 10 years or more for a drug to move through the pipeline and receive FDA approval, cuts in NIH funding now could continue to impair the development of new and better drugs for decades.
“The average cost of developing a new medicine is $1 billion to $3 billion,” Kinch says. “And at the earliest stages of research, there is more uncertainty and the risks are bigger, so pharmaceutical companies have focused their efforts on spending during later stages of development, as drugs move through clinical trials.”