Lilly to Showcase Data for Investigational Psoriasis Treatment at 24th European Academy of Dermatology and Venereology Congress
A total of 13 presentations, including a late-breaker oral presentation on
"For those with moderate-to-severe psoriasis, this chronic disease can affect many facets of their daily lives, including physical and emotional well-being, professional careers and personal relationships," said
David Ricks, Lilly senior vice president, and president, Lilly Bio-Medicines. "The data to be presented provide further evidence about ixekizumab's potential, if approved, to help more people achieve clear skin and improve their quality of life."
Data to be presented include:
- Safety and Tolerability of Ixekizumab: Analysis of Malignancies in Seven Clinical Studies of Moderate-to-Severe Plaque Psoriasis [Presenter: Strober, B.]
- Safety Profile of Ixekizumab, an Anti-Interleukin-17A Monoclonal Antibody, in Chronic Plaque Psoriasis Patients after at Least Three Years of Open-Label Treatment [Presenter: Lebwohl, M.]
Oral Poster Presentation:
- Evaluation of Ixekizumab in Patients with Psoriasis and Psoriatic Arthritis: Results of a Pooled Analysis of Three Phase 3 Studies in Moderate-to-Severe Psoriasis [Presenter: Gottlieb, A.]
- Efficacy of Ixekizumab in Patients with Plaque Psoriasis - With and Without Previous Exposure to Biologic Therapies: Results at Weeks 12 and 60 from UNCOVER-1 [Lead author: Gerdes, S.]
- Impact of Ixekizumab Treatment on Fingernail Psoriasis: Results from UNCOVER-1 [Lead author: Guenther, L.]
- The Impact of Ixekizumab Treatment on Health-Related Quality of Life in Patients with Moderate-to-Severe Psoriasis: Results from UNCOVER-1 [Lead author: Augustin, M.]
- Impact of Ixekizumab on Psoriasis Itch Severity and Other Patient-Reported Outcomes: Results from UNCOVER-1 [Lead author: Kimball, A.]
- Complete Resolution of Psoriasis is Associated with Greater Improvements in Itch and Health-Related Quality of Life: An Analysis from UNCOVER-1 [Lead author: Reich, K.]
- Safety and Tolerability of Ixekizumab: Analysis of Neutropenia in Seven Clinical Studies of Moderate-to-Severe Plaque Psoriasis [Lead author: Strober, B.]
- Safety and Tolerability of Ixekizumab: Analysis of Infections in Seven Clinical Studies of Moderate-to-Severe Plaque Psoriasis [Lead author: Papp, K.]
- Impact of Ixekizumab Treatment on Sexual Function in Moderate-to-Severe Psoriasis Patients: 12-Week Results from UNCOVER-1 [Lead author: Guenther, L.]
- Impact of Ixekizumab Treatment on Work Productivity in Patients with Moderate-to-Severe Plaque Psoriasis: Results from UNCOVER-1 [Lead author: Armstrong, A.]
- Psychosocial Burden of Chronic Plaque Psoriasis Assessed in an
Online Survey[Lead author: Cather, J.]
Ixekizumab is a monoclonal antibody with high affinity and specificity that binds to and neutralizes the pro-inflammatory cytokine interleukin-17A (IL-17A). In psoriasis, IL-17A plays a major role in driving excess keratinocyte (skin cell) proliferation and activation. Ixekizumab does not bind to cytokines IL-17B, IL-17C, IL-17D, IL-17E or IL-17F. Ixekizumab is administered via subcutaneous injection (under the skin). Ixekizumab is also in clinical development for the treatment of psoriatic arthritis.
About the UNCOVER Studies
The UNCOVER studies are double-blind, multicenter, Phase 3 studies evaluating more than 3,800 patients with moderate-to-severe psoriasis in 18 countries. UNCOVER-1 compared the safety and efficacy of different dosing regimens of ixekizumab to placebo after 12 weeks and 60 weeks of treatment. The UNCOVER-2 and -3 studies assigned patients to receive either placebo, etanercept (50 mg twice a week) or ixekizumab (80 mg every two or four weeks) for 12 weeks, following a 160 mg starting dose.